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Molecular Profile | SRSF2 P95L |
Therapy | E7107 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SRSF2 P95L | acute myeloid leukemia | predicted - sensitive | E7107 | Preclinical - Pdx | Actionable | In a preclinical study, E7107 treatment induced apoptosis and resulted in reduced tumor burden in a patient-derived xenograft (PDX) model of acute myeloid leukemia harboring SRSF2 P95L (PMID: 27135740). | 27135740 |
PubMed Id | Reference Title | Details |
---|---|---|
(27135740) | Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins. | Full reference... |