Profile Response Detail


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Molecular Profile PIK3CA H1047L
Therapy Palbociclib + PF-04691502
Indication/Tumor Type oral squamous cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA H1047L oral squamous cell carcinoma sensitive Palbociclib + PF-04691502 Preclinical - Cell line xenograft Actionable In a preclinical study, oral squamous cell carcinoma cells harboring PIK3CA H1047L demonstrated increased sensitivity to Ibrance (palbociclib) when combined with PF-04691502, and the combination treatment inhibited proliferation in cell culture, and reduced tumor growth in a cell line xenograft model (PMID: 31516747). 31516747
PubMed Id Reference Title Details
(31516747) Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance. Full reference...