Profile Response Detail

Molecular Profile KRAS G12X
Therapy Panitumumab
Indication/Tumor Type colorectal cancer
Response Type resistant
Create By spatt
Update By smockus


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12X colorectal cancer resistant Panitumumab Phase III Actionable In a Phase III trial, Vectibix (panitumumab) did not demonstrate efficacy in patients with metastatic colorectal cancer harboring KRAS mutations in codons 12 or 13 (PMID: 18316791; NCT00113763). 18316791
PubMed Id Reference Title Details
(18316791) Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. Full reference...