Profile Response Detail


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Molecular Profile PTEN L152P PTEN neg
Therapy Pictilisib
Indication/Tumor Type salivary gland carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN L152P PTEN neg salivary gland carcinoma sensitive Pictilisib Preclinical - Cell culture Actionable In a preclinical study, Pictilisib (GDC-0941) inhibited Akt phosphorylation and proliferation of salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression in culture (PMID: 30289966). 30289966
PubMed Id Reference Title Details
(30289966) Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Full reference...