Profile Response Detail

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Molecular Profile ATM negative
Therapy BAY1895344
Indication/Tumor Type collecting duct carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM negative collecting duct carcinoma predicted - sensitive BAY1895344 Case Reports/Case Series Actionable In a Phase I trial, BAY1895344 treatment resulted in a partial response with a 69% decrease in tumor size in a patient with renal collecting duct carcinoma harboring ATM protein loss, treatment was ongoing at 385 days (PMID: 32988960; NCT03188965). 32988960
PubMed Id Reference Title Details
(32988960) First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors. Full reference...