Profile Response Detail

Molecular Profile RET M918T
Therapy Sorafenib
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By spatterson
Update By spatterson

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918T colorectal cancer sensitive Sorafenib Preclinical Actionable In a preclinical study, Nexavar (sorafenib) inhibited RET phosphorylation and decreased growth of colorectal cancer cells harboring a RET M918T mutation in culture (PMID: 17664273). 17664273
PubMed Id Reference Title Details
(17664273) Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. Full reference...