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Molecular Profile EML4 - ALK TP53 V274fs
Therapy Alectinib + Ixazomib
Indication/Tumor Type lung non-small cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK TP53 V274fs lung non-small cell carcinoma sensitive Alectinib + Ixazomib Preclinical - Cell line xenograft Actionable In a preclinical study, the combination therapy of Alecensa (alectinib) and Ninlaro (ixazomib) inhibited the proliferation of non-small cell lung cancer cells harboring EML4-ALK and TP53 Q331* in culture and resulted in tumor regression in cell line xenograft models, with 3/8 achieving complete tumor regression (PMID: 33310890). 33310890
PubMed Id Reference Title Details
(33310890) Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression. Full reference...