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Molecular Profile ARID1A Y788* ARID1A M1154fs
Therapy Bevacizumab + Pembrolizumab
Indication/Tumor Type ovarian clear cell carcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A Y788* ARID1A M1154fs ovarian clear cell carcinoma predicted - sensitive Bevacizumab + Pembrolizumab Case Reports/Case Series Actionable In a clinical case study, a patient with ovarian clear cell carcinoma harboring both ARID1A Y788* and M1154fs was sensitive to the combination therapy of Keytruda (pembrolizumab) and Avastin (bevacizumab), demonstrating a decrease in serum marker, tumor regression after 3 cycles, and complete remission after 9 cycles of treatment (PMID: 33292376). 33292376
PubMed Id Reference Title Details
(33292376) Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report. Full reference...