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Molecular Profile FGFR3 - PHGDH
Therapy Ponatinib
Indication/Tumor Type childhood oligodendroglioma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 - PHGDH childhood oligodendroglioma predicted - sensitive Ponatinib Case Reports/Case Series Actionable In a clinical case study, a pediatric thalamic oligodendroglioma patient who achieved a partial response when treated with radiation therapy, was found to harbor an FGFR3-PHGDH fusion, and subsequent Iclusig (ponatinib) treatment led to a tumor reduction of 15% (compared to post-radiation scans), and an ongoing partial response lasting seven moths post-treatment initiation (PMID: 29872711). 29872711
PubMed Id Reference Title Details
(29872711) Identification and targeting of an FGFR fusion in a pediatric thalamic "central oligodendroglioma". Full reference...