Profile Response Detail


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Molecular Profile JAK2 V617F
Therapy LGH447 + Ribociclib + Ruxolitinib
Indication/Tumor Type leukemia
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 V617F leukemia predicted - sensitive LGH447 + Ribociclib + Ruxolitinib Preclinical - Cell line xenograft Actionable In a preclinical study, combination treatment with Jakafi (ruxolitinib), LGH447, and Kisqali (ribociclib) led to complete tumor regression in a cell line xenograft model of leukemia harboring JAK2 V617F (PMID: 33782031). 33782031
PubMed Id Reference Title Details
(33782031) Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms. Full reference...