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Molecular Profile | BRAF V600E MAP2K1 I99G |
Therapy | Dabrafenib |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E MAP2K1 I99G | melanoma | resistant | Dabrafenib | Preclinical - Cell culture | Actionable | In a preclinical study, melanoma cells harboring BRAF V600E and expressing MAP2K1 I99G demonstrated resistance to Tafinlar (dabrafenib) treatment in culture (PMID: 31925410). | 31925410 |
PubMed Id | Reference Title | Details |
---|---|---|
(31925410) | Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. | Full reference... |