Profile Response Detail


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Molecular Profile FGFR2 N549K
Therapy RLY-4008
Indication/Tumor Type endometrial cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 N549K endometrial cancer predicted - sensitive RLY-4008 Preclinical - Cell culture Actionable In a preclinical study, RLY-4008 treatment led to tumor regression in a cell line xenograft model of endometrial cancer harboring FGFR2 N549K (Cancer Res 2021;81(13_Suppl):Abstract nr 1455). detail...
PubMed Id Reference Title Details
RLY-4008, a novel precision therapy for FGFR2-driven cancers designed to potently and selectively inhibit FGFR2 and FGFR2 resistance mutations Full reference...