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Molecular Profile PTEN loss
Therapy Carboplatin + Paclitaxel + Sapanisertib
Indication/Tumor Type prostate cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss prostate cancer predicted - sensitive Carboplatin + Paclitaxel + Sapanisertib Case Reports/Case Series Actionable In a Phase I trial, combination treatment with Paraplatin (carboplatin), Taxol (paclitaxel), and Sapanisertib (MLN0128) led to a partial response in a castrate resistant prostate cancer harboring PTEN loss (Cancer Res 2021;81(13_Suppl):Abstract nr CT109; NCT03430882). detail...
PubMed Id Reference Title Details
Phase I study of mTORC1-2 inhibitor sapanisertib (TAK-228) in combination with carboplatin plus paclitaxelin patients with advanced solid malignancies and mTOR pathway alterations Full reference...