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Molecular Profile NTRK1 - KHDRBS1
Therapy Crizotinib
Indication/Tumor Type sarcoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 - KHDRBS1 sarcoma predicted - sensitive Crizotinib Case Reports/Case Series Actionable In a clinical case study, a patient with unclassified mesenchymal sarcoma harboring NTRK1-KHDRBS1 achieved a complete response after 3 months of Xalkori (crizotinib) treatment and remained on therapy and progression free at 45 months (PMID: 33941195). 33941195
PubMed Id Reference Title Details
(33941195) Unclassified mesenchymal sarcoma with NTRK1-KHDRBS1 gene fusion: a case report of long-term tumor-free survival with crizotinib treatment. Full reference...