Profile Response Detail


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Molecular Profile PIK3CA E545K
Therapy GSK690693 + Sirolimus
Indication/Tumor Type breast cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E545K breast cancer sensitive GSK690693 + Sirolimus Preclinical - Cell culture Actionable In a preclinical study, Rapamune (sirolimus) and GSK690693 combination treatment increased cell death compared to GSK690693 alone in a breast cancer cell line harboring PIK3CA E545K in culture (PMID: 32439931). 32439931
PubMed Id Reference Title Details
(32439931) A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity. Full reference...