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Molecular Profile | CSF3R N579Y |
Therapy | Ruxolitinib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CSF3R N579Y | hematologic cancer | sensitive | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, Jakafi (ruxolitinib) treatment inhibited colony formation and decreased viability of transformed cells expressing CSF3R N579Y in culture (PMID: 36579444). | 36579444 |
PubMed Id | Reference Title | Details |
---|---|---|
(36579444) | A novel colony stimulating factor 3 receptor activating mutation identified in a patient with chronic neutrophilic leukemia. | Full reference... |