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Molecular Profile | BTK A428D |
Therapy | Vecabrutinib |
Indication/Tumor Type | diffuse large B-cell lymphoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK A428D | diffuse large B-cell lymphoma | resistant | Vecabrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK A428D demonstrated resistance to Vecabrutinib (SNS-062) in culture (PMID: 35196427). | 35196427 |
PubMed Id | Reference Title | Details |
---|---|---|
(35196427) | Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. | Full reference... |