Profile Response Detail


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Molecular Profile BTK C481S
Therapy Edralbrutinib
Indication/Tumor Type mantle cell lymphoma
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK C481S mantle cell lymphoma predicted - resistant Edralbrutinib Preclinical - Cell culture Actionable In a preclinical study, Edralbrutinib (TG-1701) treatment resulted in reduced sensitivity in a mantle cell lymphoma cell line expressing BTK C481S compared to the parental wild-type BTK cell line in culture (PMID: 34551904). 34551904
PubMed Id Reference Title Details
(34551904) Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non-Hodgkin Lymphoma. Full reference...