Profile Response Detail


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Molecular Profile RET C634W
Therapy APS03118
Indication/Tumor Type thyroid cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634W thyroid cancer predicted - sensitive APS03118 Preclinical - Cell line xenograft Actionable In a preclinical study, APS03118 treatment inhibited proliferation of a thyroid cancer cell line harboring RET C634W in culture and inhibited tumor growth in a xenograft model (J Clin Oncol 40, no. 16_suppl (June 1, 2022)). detail...
PubMed Id Reference Title Details
The development of APS03118, a potent next-generation RET inhibitor for treating RET-inhibitor-resistant patients. Full reference...