Profile Response Detail


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Molecular Profile NRAS Q61K
Therapy Everolimus + RO5126766
Indication/Tumor Type thyroid cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS Q61K thyroid cancer predicted - sensitive Everolimus + RO5126766 Case Reports/Case Series Actionable In a Phase I trial, the combination of Afinitor (everolimus) and RO5126766 (VS-6766) resulted in a partial response in a patient with thyroid cancer harboring NRAS Q61K (Journal of Clinical Oncology 2022 40:16_suppl, 9018-9018; NCT02407509). detail...
PubMed Id Reference Title Details
Phase I trial of the RAF/MEK clamp VS-6766 in combination with everolimus using an intermittent schedule with expansion in NSCLC across multiple KRAS variants. Full reference...