Profile Response Detail


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Molecular Profile NRAS wild-type
Therapy Fluorouracil + Irinotecan + Leucovorin + Panitumumab
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS wild-type colorectal cancer predicted - sensitive Fluorouracil + Irinotecan + Leucovorin + Panitumumab Phase III Actionable In a Phase III clinical trial, the combination of Vectibix (panitumumab) and FOLFIRI improved progression-free survival and median overall survival in patients with RAS wild-type colorectal cancer compared to FOLFIRI treatment alone (PMID: 26341920). 26341920
PubMed Id Reference Title Details
(26341920) Analysis of KRAS/NRAS Mutations in a Phase III Study of Panitumumab with FOLFIRI Compared with FOLFIRI Alone as Second-line Treatment for Metastatic Colorectal Cancer. Full reference...