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Molecular Profile | NTRK2 R458G |
Therapy | Crenolanib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NTRK2 R458G | hematologic cancer | sensitive | Crenolanib | Preclinical - Cell culture | Actionable | In a preclinical study, Crenolanib (CP-868596) inhibited viability of transformed cells expressing NTRK2 R458G in culture (PMID: 32315394). | 32315394 |
PubMed Id | Reference Title | Details |
---|---|---|
(32315394) | Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms. | Full reference... |