Profile Response Detail

Molecular Profile KRAS G12D
Therapy LY294002
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By smockus
Update By smockus

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D Advanced Solid Tumor sensitive LY294002 Preclinical Actionable In a preclinical study, LY294002 reduced phosphorylation of Akt in pancreatic epithelial cells expressing Kras G12D (PMID: 22871572). 22871572
PubMed Id Reference Title Details
(22871572) KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. Full reference...