Profile Response Detail

Molecular Profile KRAS G12D
Therapy PD-0325901
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By smockus
Update By smockus

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D lung adenocarcinoma sensitive PD-0325901 Preclinical Actionable In a preclinical study, PD-0325901 inhibited growth of lung adenocarcinomas in mouse models expressing Kras G12D (PMID: 22684718). 22684718
PubMed Id Reference Title Details
(22684718) Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice. Full reference...