Molecular Profile | KRAS G12D |
Therapy | PD-0325901 |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | sensitive |
Create By | smockus |
Update By | smockus |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | KRAS G12D | lung adenocarcinoma | sensitive | PD-0325901 | Preclinical | Actionable | In a preclinical study, PD-0325901 inhibited growth of lung adenocarcinomas in mouse models expressing Kras G12D (PMID: 22684718). | 22684718 |
---|
PubMed Id | Reference Title | Details |
---|---|---|
(22684718) | Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice. | Full reference... |