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Molecular Profile BRAF V600E PTEN loss
Therapy Dabrafenib + Enzalutamide + Trametinib
Indication/Tumor Type melanoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E PTEN loss melanoma predicted - sensitive Dabrafenib + Enzalutamide + Trametinib Preclinical Actionable In a preclinical study, addition of Xtandi (enzalutamide) to Tafinlar (dabrafenib) and Mekinist (trametinib) combination therapy improved tumor control and led to a greater reduction in tumor volume in an allograft mouse model of melanoma harboring BRAF V600E and PTEN loss (PMID: 35705814). 35705814
PubMed Id Reference Title Details
(35705814) Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy. Full reference...