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Molecular Profile | BTK C481S |
Therapy | AS-1763 |
Indication/Tumor Type | diffuse large B-cell lymphoma activated B-cell type |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK C481S | diffuse large B-cell lymphoma activated B-cell type | sensitive | AS-1763 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AS-1763 inhibited proliferation of an activated B cell-like (ABC) diffuse large B-cell lymphoma cell line expressing BTK C481S in culture and inhibited tumor growth in a cell line xenograft model (PMID: 34529443). | 34529443 |
PubMed Id | Reference Title | Details |
---|---|---|
(34529443) | Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase. | Full reference... |