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Molecular Profile | BTK C481S |
Therapy | Duvelisib |
Indication/Tumor Type | chronic lymphocytic leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK C481S | chronic lymphocytic leukemia | sensitive | Duvelisib | Preclinical - Pdx | Actionable | In a preclinical study, Copiktra (duvelisib) treatment resulted in a reduction of leukemia cells in the spleen of a patient-derived xenograft (PDX) model of chronic lymphocytic leukemia harboring BTK C481S (PMID: 37071496). | 37071496 |
PubMed Id | Reference Title | Details |
---|---|---|
(37071496) | Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model. | Full reference... |