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Molecular Profile | ERBB3 positive |
Therapy | AMT-562 |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB3 positive | colon cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive colon cancer with a complete response in 4 of 5 mice and inhibited growth in patient-derived organoids in culture (PMID: 37302522). | 37302522 |
PubMed Id | Reference Title | Details |
---|---|---|
(37302522) | AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors. | Full reference... |