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Molecular Profile BRAF V600E MAP2K1 K57T
Therapy Cetuximab + Fluorouracil + Leucovorin + Vemurafenib
Indication/Tumor Type colorectal cancer
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E MAP2K1 K57T colorectal cancer predicted - resistant Cetuximab + Fluorouracil + Leucovorin + Vemurafenib Case Reports/Case Series Actionable In a Phase II trial (MODUL), a patient with metastatic colorectal cancer harboring BRAF V600E was found to have acquired MAP2K1 K57T prior to progression on treatment with the combination of Zelboraf (vemurafenib), Erbitux (cetuximab), Adrucil (fluorouracil), and Wellcovorin (leucovorin) (PMID: 36921494; NCT02291289). 36921494
PubMed Id Reference Title Details
(36921494) Clinical and exploratory biomarker findings from the MODUL trial (Cohorts 1, 3 and 4) of biomarker-driven maintenance therapy for metastatic colorectal cancer. Full reference...