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Molecular Profile PIK3CA R88Q
Therapy Alpelisib + Tipifarnib
Indication/Tumor Type tonsil squamous cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA R88Q tonsil squamous cell carcinoma predicted - sensitive Alpelisib + Tipifarnib Case Reports/Case Series Actionable In a Phase I/II trial (KURRENT-HN), the combination of Piqray (alpelisib) and Zarnestra (tipifarnib) resulted in a partial response with an 84% reduction in the target lesions and a complete response in the lung in a patient with metastatic squamous cell carcinoma of the tonsil harboring PIK3CA R88Q, with response ongoing at 27 weeks (PMID: 37339176; NCT04997902). 37339176
PubMed Id Reference Title Details
(37339176) Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in PIK3CA- and HRAS-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity. Full reference...