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Molecular Profile | BTK G409R |
Therapy | Vecabrutinib |
Indication/Tumor Type | mantle cell lymphoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK G409R | mantle cell lymphoma | resistant | Vecabrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, a mantle cell lymphoma cell line developed resistance to Vecabrutinib (SNS-062) after prolonged exposure in culture, and was subsequently found to have acquired BTK G409R (PMID: 36661329). | 36661329 |
PubMed Id | Reference Title | Details |
---|---|---|
(36661329) | Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors. | Full reference... |