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Molecular Profile | BTK D539H |
Therapy | ARQ 531 |
Indication/Tumor Type | mantle cell lymphoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK D539H | mantle cell lymphoma | sensitive | ARQ 531 | Preclinical - Cell culture | Actionable | In a preclinical study, ARQ 531 inhibited viability of a mantle cell lymphoma cell line harboring BTK D539H in culture (PMID: 36661329). | 36661329 |
PubMed Id | Reference Title | Details |
---|---|---|
(36661329) | Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors. | Full reference... |