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Molecular Profile PIK3CA E453K PIK3CA E545A
Therapy A-1331852 + Alpelisib
Indication/Tumor Type stomach cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E453K PIK3CA E545A stomach cancer sensitive A-1331852 + Alpelisib Preclinical - Cell culture Actionable In a preclinical study, the combination of Piqray (alpelisib) and A-1331852 synergistically inhibited viability in a gastric cancer cell line harboring PIK3CA E545A and E453K in culture (PMID: 37493631). 37493631
PubMed Id Reference Title Details
(37493631) CBF-Beta Mitigates PI3K-Alpha-Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer. Full reference...