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Molecular Profile | BTK C481R |
Therapy | Ibrutinib |
Indication/Tumor Type | diffuse large B-cell lymphoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK C481R | diffuse large B-cell lymphoma | resistant | Ibrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, diffuse large B-cell lymphoma cell lines expressing BTK C481R demonstrated resistance to Imbruvica (ibrutinib) in culture (PMID: 36183831). | 36183831 |
PubMed Id | Reference Title | Details |
---|---|---|
(36183831) | BTK kinase activity is dispensable for the survival of diffuse large B-cell lymphoma. | Full reference... |