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Molecular Profile KMT2A rearrange
Therapy Fingolimod
Indication/Tumor Type acute lymphoblastic leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A rearrange acute lymphoblastic leukemia sensitive Fingolimod Preclinical - Cell culture Actionable In a preclinical study, Gilenya (fingolimod) inhibited proliferation and induced cell death and cell cycle arrest in an acute lymphoblastic leukemia cell line harboring KMT2A rearrangement in culture (PMID: 37891368). 37891368
PubMed Id Reference Title Details
(37891368) SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. Full reference...