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Molecular Profile BRAF V600E PIK3CA E542K
Therapy Dasatinib + MK2206 + Trametinib
Indication/Tumor Type thyroid gland anaplastic carcinoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E PIK3CA E542K thyroid gland anaplastic carcinoma resistant Dasatinib + MK2206 + Trametinib Preclinical - Cell culture Actionable In a preclinical study, the addition of MK2206 did not sensitize an anaplastic thyroid cancer cell line harboring BRAF V600E and PIK3CA E542k to Sprycel (dasatinib) and Mekinist (trametinib) combination treatment in culture (PMID: 37713162). 37713162
PubMed Id Reference Title Details
(37713162) AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibition. Full reference...