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Molecular Profile | PIK3CA wild-type |
Therapy | Lapatinib + Paclitaxel + Trastuzumab |
Indication/Tumor Type | Her2-receptor positive breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA wild-type | Her2-receptor positive breast cancer | sensitive | Lapatinib + Paclitaxel + Trastuzumab | Phase II | Actionable | In a Phase II trial, the combination of Taxol (paclitaxel) plus Herceptin (trastuzumab) and Tykerb (lapatinib) resulted in a higher pathologic complete remission rate in ERBB2 (HER2)-receptor positive breast cancer patients with PIK3CA wild-type compared to those harboring a PIK3CA mutation (PMID: 26245675). | 26245675 |
PubMed Id | Reference Title | Details |
---|---|---|
(26245675) | Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer. | Full reference... |