Profile Response Detail


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Molecular Profile PTEN L194fs
Therapy Ipilimumab + Nivolumab + Temsirolimus
Indication/Tumor Type thyroid cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN L194fs thyroid cancer predicted - sensitive Ipilimumab + Nivolumab + Temsirolimus Case Reports/Case Series Actionable In a clinical case study, the addition of Torisel (temsirolimus) to the combination treatment of Yervoy (ipilimumab) and Opdivo (nivolumab) resulted in a partial response with a decrease in target lesion size in a patient with poorly differentiated thyroid cancer harboring PTEN L194fs, along with TP53 F270S, who remained on treatment for 6 months (PMID: 38356955). 38356955
PubMed Id Reference Title Details
(38356955) Deep response to a combination of mTOR inhibitor temsirolimus and dual immunotherapy of nivolumab/ipilimumab in poorly differentiated thyroid carcinoma with PTEN mutation: a case report and literature review. Full reference...