Profile Response Detail

Molecular Profile NPM1-ALK ALK S1206C
Therapy Ceritinib
Indication/Tumor Type Advanced Solid Tumor
Response Type decreased response
Create By c-seddy
Update By tyin

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NPM1-ALK ALK S1206C Advanced Solid Tumor decreased response Ceritinib Preclinical - Cell culture Actionable In a preclinical study, Zykadia (ceritinib) inhibited growth of transformed cells expressing NPM1-ALK with ALK S1206C to a lesser degree than cells expressing NPM1-ALK in culture (PMID: 25421750). 25421750
PubMed Id Reference Title Details
(25421750) Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma. Full reference...