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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NRAS G12D||acute myeloid leukemia||sensitive||Binimetinib||Preclinical||Actionable||In a preclinical study, Binimetinib (MEK162) inhibited growth of acute myeloid leukemia cells that have been demonstrated to harbor NRAS G12D in culture and decreased disease burden in xenograft models with NRAS G12D (PMID: 24569456, PMID: 11238126).||24569456 11238126|
|PubMed Id||Reference Title||Details|
|(24569456)||Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.||Full reference...|
|(11238126)||Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.||Full reference...|