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Molecular Profile | FLT3 exon 14 ins FLT3 F691L |
Therapy | Ningetinib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 F691L | acute myeloid leukemia | sensitive | Ningetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Ningetinib (CT053PTSA) decreased leukemic burden in a cell line xenograft model of acute myeloid leukemia harboring a FLT3-ITD and expressing FLT3 F691L (PMID: 38978049). | 38978049 |
PubMed Id | Reference Title | Details |
---|---|---|
(38978049) | Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia. | Full reference... |