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Molecular Profile | MST1R over exp |
Therapy | IMC-41A10 |
Indication/Tumor Type | colon cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MST1R over exp | colon cancer | predicted - sensitive | IMC-41A10 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, IMC-41A10 inhibited MST1R (RON) downstream signaling and migration of colon cancer cells in culture, and reduced tumor growth in MST1R-positive colorectal cancer xenograft models (PMID: 16982759). | 16982759 |
PubMed Id | Reference Title | Details |
---|---|---|
(16982759) | Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member. | Full reference... |