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Molecular Profile NTRK2 positive
Therapy GNF-4256 + Irinotecan + Temozolomide
Indication/Tumor Type neuroblastoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 positive neuroblastoma sensitive GNF-4256 + Irinotecan + Temozolomide Preclinical - Cell line xenograft Actionable In a preclinical study, GNF-4256 worked synergistically with Camptosar (irinotecan) and Temodar (temozolomide), resulting in growth inhibition and an increased event-free survival in cell line xenograft models of neuroblastoma expressing Ntrk2 (PMID: 25394774). 25394774
PubMed Id Reference Title Details
(25394774) TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. Full reference...