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Molecular Profile | PIK3CA N345K |
Therapy | Lapatinib |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA N345K | breast cancer | sensitive | Lapatinib | Preclinical | Actionable | In a preclinical study, Tykerb (lapatinib) inhibited survival of transformed breast epithelial cell lines overexpressing PIK3CA N345K in culture (PMID: 26627007). | 26627007 |
PubMed Id | Reference Title | Details |
---|---|---|
(26627007) | Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations. | Full reference... |