Profile Response Detail

Molecular Profile KRAS mutant
Therapy Fluorouracil + Leucovorin + Necitumumab + Oxaliplatin
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive
Create By spatt
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant colorectal cancer predicted - sensitive Fluorouracil + Leucovorin + Necitumumab + Oxaliplatin Phase II Actionable In a Phase II clinical trial, the combination of Portrazza (necitumumab) and FOLFOX in colorectal cancer patients resulted in an objective response rate (ORR) of 63.6% (28/44) in the overall intent-to-treat population, with an ORR of 56.5% (5/9; all partial responses), and stable disease in 44.4% (4/9) of KRAS-mutant patients (PMID: 26766738). 26766738
PubMed Id Reference Title Details
(26766738) Phase II study of necitumumab plus modified FOLFOX6 as first-line treatment in patients with locally advanced or metastatic colorectal cancer. Full reference...