Profile Response Detail


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Molecular Profile MAP2K1 K57T
Therapy Panitumumab + Trametinib
Indication/Tumor Type colorectal cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 K57T colorectal cancer sensitive Panitumumab + Trametinib Case Reports/Case Series Actionable In a clinical case study, a combination of Vectibix (panitumumab) and Mekinist (trametinib) caused tumor regression in a patient’s colorectal cancer metastases harboring MAP2K1 K57T after being identified pre-clinically as a combination likely to inhibit MAP2K1 K57T expressing colorectal cancer (PMID: 26644315). 26644315
PubMed Id Reference Title Details
(26644315) Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer. Full reference...