Profile Response Detail

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Molecular Profile TP53 mutant
Therapy Pazopanib
Indication/Tumor Type sarcoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant sarcoma sensitive Pazopanib Clinical Study - Cohort Actionable In a retrospective analysis, advanced sarcoma patients with TP53 mutations displayed improved progression-free survival (208 vs 136 days, p=0.036) relative to patients with wild-type TP53 when treated with Votrient (pazopanib) (PMID: 26646755). 26646755
PubMed Id Reference Title Details
(26646755) TP53 mutational status is predictive of pazopanib response in advanced sarcomas. Full reference...