Profile Response Detail

Molecular Profile KRAS G13D
Therapy Luminespib
Indication/Tumor Type colon cancer
Response Type sensitive
Create By cstatz
Update By tyin


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G13D colon cancer sensitive Luminespib Preclinical - Cell line xenograft Actionable In a preclinical study, a colon cancer cell line harboring KRAS G13D demonstrated increased sensitivity to Luminespib (AUY922) compared to cell lines with wild-type KRAS, resulting in decreased viability and increased apoptosis in culture and reduced tumor growth in xenograft models (PMID: 26832792). 26832792
PubMed Id Reference Title Details
(26832792) Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress. Full reference...