Profile Response Detail


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Molecular Profile SMO A459V
Therapy Vismodegib
Indication/Tumor Type Advanced Solid Tumor
Response Type decreased response


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMO A459V Advanced Solid Tumor decreased response Vismodegib Preclinical Actionable In a preclinical study, primary cerebellar granule neuron precursor cells over expressing SMO A459V on the background of PTCH1 and TP53 deletion demonstrated reduced response to Erivedge (vismodegib) induced growth inhibition in cell culture (PMID: 25759019). 25759019
PubMed Id Reference Title Details
(25759019) Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Full reference...