Molecular Profile | SMO V321M |
Therapy | JQ1 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Create By | tyin |
Update By | tyin |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | SMO V321M | Advanced Solid Tumor | sensitive | JQ1 | Preclinical | Actionable | In a preclinical study, JQ1 inhibited proliferation of primary cerebellar granule neuron precursor cells over expressing SMO V321M on the background of PTCH1 and TP53 deletion in cell culture (PMID: 25759019). | 25759019 |
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PubMed Id | Reference Title | Details |
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(25759019) | Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. | Full reference... |